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KMID : 0811720140180060457
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Korean Journal of Physiology & Pharmacology
2014 Volume.18 No. 6 p.457 ~ p.460
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Long-term Synaptic Plasticity: Circuit Perturbation and Stabilization
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Park Joo-Min
Jung Sung-Cherl
Eun Su-Yong
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Abstract
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At central synapses, activity-dependent synaptic plasticity has a crucial role in information pro-cessing, storage, learning, and memory under both physiological and pathological conditions. One widely accepted model of learning mechanism and information processing in the brain is Hebbian Plasticity: long-term potentiation (LTP) and long-term depression (LTD). LTP and LTD are respectively activity-dependent enhancement and reduction in the efficacy of the synapses, which are rapid and synapse-specific processes. A number of recent studies have a strong focal point on the critical importance of another distinct form of synaptic plasticity, non-Hebbian plasticity. Non-Hebbian plasticity dynamically adjusts synaptic strength to maintain stability. This process may be very slow and occur cell-widely. By putting them all together, this mini review defines an important conceptual difference between Hebbian and non-Hebbian plasticity.
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KEYWORD
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Hebbian Plasticity, Long-term depression, Long-term potentiation, Synapse, Synaptic Plasticity
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